&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;In&lt;/span&gt; &lt;a href=&quot;https://cms.pulse-clinic.com/ass-juice-part-1-the-biology-of-ass-juice&quot;&gt;Part 1 (Ass Juice Part 1 - The Anatomy &amp;amp; Biology Of Ass Juice),&lt;/a&gt;&amp;nbsp;&lt;span style=&quot;color: #99ccff;&quot;&gt;we already learned about where and how the mucus is produce and release form the Goblet cells. I&#39;m making you love the Goblet Cells right? LOL&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Now since I&#39;ve been curious about how to make it more juicy and easier for fingering, fucking and fisting, how can we stimulate the goblet cells to produce more mucins and release more mucus?&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Let&#39;s go find out!&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Goblet cells usually assume a distinctly polarized morphology, with the nucleus and&amp;nbsp;Golgi apparatus&amp;nbsp;basally situated. The remaining cellular organelles are aligned along the lateral margins of the cell, compressed to these regions by the abundant, membrane-bound mucus-secreting granules within the cell interior. Mucin&amp;nbsp;secreted from the goblet cells is largely composed of highly&amp;nbsp;glycosylated proteins&amp;nbsp;suspended in an&amp;nbsp;electrolyte solution. However, recent discoveries have changed this and placed these cells at the center stage of our understanding of mucosal biology and the immunology of the intestinal tract.&lt;/span&gt;&amp;nbsp;&lt;br /&gt;&lt;strong&gt;The surface colonic goblet cells secrete continuously to maintain the inner mucus layer.&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;, &lt;span style=&quot;color: #99ccff;&quot;&gt;whereas goblet cells of the colonic and small intestinal crypts secrete upon stimulation.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;The copious amounts of mucin produced by goblet cells is crucial in providing lubrication for the passage of feces.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;img src=&quot;https://www1.udel.edu/biology/Wags/histopage/colorpage/cli/clirp.GIF&quot; width=&quot;894&quot; height=&quot;587&quot; /&gt;&lt;/p&gt;
&lt;h2 id=&quot;Sec5&quot; class=&quot;c-article-section__title js-section-title js-c-reading-companion-sections-item&quot;&gt;GOBLET CELL EXOCYTOSIS&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Secretion of mucins can take place in at least two ways: regulated vesicle secretion and compound exocytosis.&amp;nbsp;&lt;/span&gt;&lt;br /&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;1.&amp;nbsp;&amp;nbsp;Regulated vesicle secretion,&amp;nbsp;This process includes the fusion of single vesicles with the plasma membrane mediated by typical vesicle exocytosis components like Syntaxins, Munc18, VAMP, and SNAP proteins.&amp;nbsp;&lt;/span&gt;&lt;br /&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;2.&amp;nbsp;Compound exocytosis is a more dramatic event where most of the vesicles that make up the goblet cell theca fuse and empty their content. There are no molecular studies on this type of secretion, but there are very clear morphological studies that show that the whole cell essentially explodes during this secretory process.&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h2 id=&quot;Sec7&quot; class=&quot;c-article-section__title js-section-title js-c-reading-companion-sections-item&quot;&gt;INDUCED GOBLET CELL MUCUS SECRETION&lt;/h2&gt;
&lt;div id=&quot;Sec7-content&quot; class=&quot;c-article-section__content&quot;&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Exocytosis of mucin granulae can also be regulated by intracellular Ca&lt;sup&gt;2+&lt;/sup&gt;&amp;nbsp;levels and Ca&lt;sup&gt;2+&lt;/sup&gt;&amp;nbsp;mobilizing agents such as acetylcholine and histamine are potent inducers of intestinal mucus secretion.&lt;/span&gt; &lt;span style=&quot;text-decoration: underline;&quot;&gt;&lt;strong&gt;Acetylcholine&lt;/strong&gt;&lt;/span&gt; &lt;span style=&quot;color: #99ccff;&quot;&gt;is by far the most studied mucus secretagogue and has been shown to induce mucus secretion in both the small and large intestine of mouse, rat, and rabbit, and in the human colon.&lt;sup&gt;2, 1, 3, 4 5&lt;/sup&gt;&lt;/span&gt;&amp;nbsp;&lt;strong&gt;Stimulation with acetylcholine or other cholinergic agonists such as carbachol results in a rapid transient increase in mucus secretion rates that reverts to baseline values within 30&amp;thinsp;min.&lt;/strong&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&amp;nbsp;Acetylcholine primarily targets the goblet cells in the small intestinal crypts, resulting in more or less complete emptying of the stored mucin granule pool. The villus goblet cells in the small intestine and the surface goblet cells in the colon do not respond to acetylcholine or carbachol with exocytosis. Although cholinergic agonists are inducers of mucus secretion in both the small and large intestine, the small intestine is by far most sensitive to carbachol.&lt;sup&gt;2, 5&lt;/sup&gt;&amp;nbsp;Conversely, the opposite pattern is instead true for histamine that induces mucus secretion in the colon, but not in the small intestine.&lt;sup&gt;3, 4&amp;nbsp;&amp;nbsp;&lt;/sup&gt;The immune modulator prostaglandin E&lt;sub&gt;2&lt;/sub&gt;&amp;nbsp;has been shown to induce mucus secretion in rat colon and mouse small intestine, but only induces fluid secretion in the human colon.&lt;sup&gt;5, 6&lt;/sup&gt;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&lt;/p&gt;
&lt;h2 id=&quot;Sec7&quot; class=&quot;c-article-section__title js-section-title js-c-reading-companion-sections-item&quot;&gt;Next Step, Read More About Acetylcholine.&lt;/h2&gt;
&lt;/div&gt;

&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;REFERENCES&lt;/p&gt;
&lt;ol&gt;
&lt;li&gt;Specian, D. &amp;amp; Neutra, M.R. Mechanism of rapid mucus secretion in goblet cells stimulated by acetylcholine.&amp;nbsp;&lt;em&gt;J. Cell Biol.&lt;/em&gt;&amp;nbsp;&lt;strong&gt;85&lt;/strong&gt;, 626&amp;ndash;640 (1980).&lt;/li&gt;
&lt;li&gt;Ermund, A., Schutte, A., Johansson, M.E.V., Gustafsson, J.K. &amp;amp; Hansson, G.C. Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer&#39;s patches.&amp;nbsp;&lt;em&gt;Am. J. Physiol. Gastroint. Liver Physiol&lt;/em&gt;&amp;nbsp;&lt;strong&gt;305&lt;/strong&gt;, G341&amp;ndash;G347 (2013).&lt;/li&gt;
&lt;li&gt;Neutra, M.R., O&#39;Malley, L.J. &amp;amp; Specian, R.D. Regulation of intestinal goblet cell secretion. II. A survey of potentid secretugogues.&amp;nbsp;&lt;em&gt;Am. J. Physiol. Gastroint. Liver Physiol.&lt;/em&gt;&amp;nbsp;&lt;strong&gt;242&lt;/strong&gt;, G380&amp;ndash;G387 (1982).&lt;/li&gt;
&lt;li&gt;Halm, D.R. &amp;amp; Halm, S.T. Secretagogue response of goblet cells and columnar cells in human colonic crypts.&amp;nbsp;&lt;em&gt;Am. J. Physiol. Cell Physiol.&lt;/em&gt;&amp;nbsp;&lt;strong&gt;278&lt;/strong&gt;, C212&amp;ndash;C233 (2000).&lt;/li&gt;
&lt;li&gt;Gustafsson, J.K., Ermund, A., Johansson, M.E.V., Schutte, A., Hansson, G.C. &amp;amp; Sjovall, H. An&amp;nbsp;&lt;em&gt;ex vivo&lt;/em&gt;&amp;nbsp;method for studying mucus formation, properties and thickness in human colonic biopsies and mouse small and large intestinal explants.&amp;nbsp;&lt;em&gt;Am. J. Physiol. Gastrointest. Liver. Physiol.&lt;/em&gt;&amp;nbsp;&lt;strong&gt;302&lt;/strong&gt;, G430&amp;ndash;G438 (2012).&lt;/li&gt;
&lt;li&gt;Garcia, M.A., Yang, N. &amp;amp; Quinton, P.M. Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion.&amp;nbsp;&lt;em&gt;J. Clin. Invest.&lt;/em&gt;&amp;nbsp;&lt;strong&gt;119&lt;/strong&gt;, 2613&amp;ndash;2622 (2009).&lt;/li&gt;
&lt;li&gt;George M,&amp;nbsp;&lt;a href=&quot;https://www.researchgate.net/publication/275048146_New_developments_in_goblet_cell_mucus_secretion_and_function&quot;&gt;https://www.researchgate.net/publication/275048146_New_developments_in_goblet_cell_mucus_secretion_and_function&lt;/a&gt;&lt;/li&gt;
&lt;/ol&gt;

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