&lt;h2&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;Overview&lt;/strong&gt;&lt;/span&gt;&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Assessing individuals with chronic myelogenous leukemia and Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia undergoing tyrosine kinase inhibitor (TKI) therapy, showing signs of treatment failure.&lt;/span&gt;&lt;/p&gt;
&lt;hr /&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;WHAT IS IT USED FOR?&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;ul&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Assessing individuals diagnosed with chronic myelogenous leukemia and Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia undergoing tyrosine kinase inhibitor (TKI) treatment, who seem to be experiencing treatment ineffectiveness.&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;The recommended first examination to detect acquired BCR-ABL1 mutations linked to TKI resistance.&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;METHOD NAME&lt;br /&gt;&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Reverse Transcription Polymerase Chain Reaction (RT-PCR) with Sanger Sequencing&lt;/span&gt;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;&lt;br /&gt;AVAILABILITY&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;TBC&lt;/span&gt;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;REPORTING NAME&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;BCR/ABL1 Mutation, Sequencing&lt;/span&gt;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #808080;&quot;&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;OTHER NAME&lt;/strong&gt;&lt;/span&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;ul&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;E255K&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;E355G&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;F317L&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;F369V&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;G250E&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;H396R&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;M244V&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;M351T&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Q252H&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;T315I&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Y253F&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Y253H&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;T315A&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;V299L&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Tyrosine kinase inhibitor (TKI)&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Kinase domain mutation, ABL&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Imatinib resistance&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Chronic myeloid leukemia&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Chronic myelogenous leukemia (CML)&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;BCR-ABL1&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;BCR/ABL&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;BCR ABL&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Acute lymphoblastic leukemia (ALL)&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;div class=&quot;flex-1 overflow-hidden&quot;&gt;
&lt;div class=&quot;react-scroll-to-bottom--css-ffwkx-79elbk h-full&quot;&gt;
&lt;div class=&quot;react-scroll-to-bottom--css-ffwkx-1n7m0yu&quot;&gt;
&lt;div class=&quot;flex flex-col text-sm pb-9&quot;&gt;
&lt;div class=&quot;w-full text-token-text-primary&quot; dir=&quot;auto&quot; data-testid=&quot;conversation-turn-7&quot;&gt;
&lt;div class=&quot;px-4 py-2 justify-center text-base md:gap-6 m-auto&quot;&gt;
&lt;div class=&quot;flex flex-1 text-base mx-auto gap-3 juice:gap-4 juice:md:gap-6 md:px-5 lg:px-1 xl:px-5 md:max-w-3xl lg:max-w-[40rem] xl:max-w-[48rem] group final-completion&quot;&gt;
&lt;div class=&quot;relative flex w-full flex-col agent-turn&quot;&gt;
&lt;div class=&quot;flex-col gap-1 md:gap-3&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;div class=&quot;w-full pt-2 md:pt-0 dark:border-white/20 md:border-transparent md:dark:border-transparent md:w-[calc(100%-.5rem)]&quot;&gt;&lt;form class=&quot;stretch mx-2 flex flex-row gap-3 last:mb-2 md:mx-4 md:last:mb-6 lg:mx-auto lg:max-w-2xl xl:max-w-3xl&quot;&gt;
&lt;div class=&quot;relative flex h-full flex-1 flex-col&quot;&gt;
&lt;div class=&quot;flex w-full items-center&quot;&gt;
&lt;div class=&quot;overflow-hidden [&amp;amp;:has(textarea:focus)]:border-token-border-xheavy [&amp;amp;:has(textarea:focus)]:shadow-[0_2px_6px_rgba(0,0,0,.05)] flex flex-col w-full flex-grow relative border dark:text-white rounded-2xl bg-token-main-surface-primary border-token-border-medium&quot;&gt;
&lt;div data-grammarly-part=&quot;button&quot;&gt;
&lt;div&gt;
&lt;div&gt;
&lt;div class=&quot;amkYk&quot;&gt;
&lt;div&gt;
&lt;div class=&quot;ptGJG&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/form&gt;&lt;/div&gt;

&lt;h3 id=&quot;SpecimenType-title&quot;&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;SPECIMEN TYPE&lt;/strong&gt;&amp;nbsp;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Whole Blood&lt;br /&gt;&lt;/span&gt;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;SHIPPING INSTRUCTIONS&lt;br /&gt;&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;TBC&lt;/span&gt;&lt;/p&gt;
&lt;div class=&quot;flex-1 overflow-hidden&quot;&gt;
&lt;div class=&quot;react-scroll-to-bottom--css-ffwkx-79elbk h-full&quot;&gt;
&lt;div class=&quot;react-scroll-to-bottom--css-ffwkx-1n7m0yu&quot;&gt;
&lt;div class=&quot;flex flex-col text-sm pb-9&quot;&gt;
&lt;div class=&quot;w-full text-token-text-primary&quot; dir=&quot;auto&quot; data-testid=&quot;conversation-turn-7&quot;&gt;
&lt;div class=&quot;px-4 py-2 justify-center text-base md:gap-6 m-auto&quot;&gt;
&lt;div class=&quot;flex flex-1 text-base mx-auto gap-3 juice:gap-4 juice:md:gap-6 md:px-5 lg:px-1 xl:px-5 md:max-w-3xl lg:max-w-[40rem] xl:max-w-[48rem] group final-completion&quot;&gt;
&lt;div class=&quot;relative flex w-full flex-col agent-turn&quot;&gt;
&lt;div class=&quot;flex-col gap-1 md:gap-3&quot;&gt;
&lt;div class=&quot;flex flex-grow flex-col max-w-full&quot;&gt;
&lt;div class=&quot;min-h-[20px] text-message flex flex-col items-start gap-3 whitespace-pre-wrap break-words [.text-message+&amp;amp;]:mt-5 overflow-x-auto&quot; dir=&quot;auto&quot; data-message-author-role=&quot;assistant&quot; data-message-id=&quot;51364005-ca87-4f44-9ae9-16e243c2b60c&quot;&gt;
&lt;div class=&quot;markdown prose w-full break-words dark:prose-invert light&quot;&gt;
&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;SPECIMEN COLLECTION&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;&lt;strong&gt;Container/Tube:&lt;/strong&gt; Lavender top (EDTA)&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;&lt;strong&gt;Specimen Volume:&lt;/strong&gt; 10 mL&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;Collection Instructions:&lt;/strong&gt; &lt;/span&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Gently invert the blood sample multiple times to ensure thorough mixing.&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Submit the entire blood specimen in its original tube; do not divide it into smaller portions.&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Clearly mark the specimen as blood.&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;

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BCR/ABL1, Tyrosine Kinase Inhibitor Resistance, Kinase Domain Mutation Screen, Sanger Sequencing, Varies